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Adjunct Faculty
Professor, Department of Plant Pathology, Physiology and Weed Science
Phone: (540) 231-7318
Email: btyler@vbi.vt.edu
Fax: 540 231 2606
Administrative Specialist: Maureen Lawrence-Kuether
Phone: (540) 231-3669
Email: mlawre04@vbi.vt.edu
Fax:540-231-2606
Tyler Research Group |
Publications
| Oomycete Molecular Genetics Research Collaboration Network | Plant-Associated Microbe Gene Ontology
Professional Preparation
- University of Melbourne, molecular biology, Ph.D., 1981
- Monash University, genetics, biochemistry, and mathematics, B.Sc., 1977
- University of Georgia, postdoctoral training, 1982-84
Fellowships - 1978-1981 Australian Government Postgraduate Research Award
- 1982-1982 CSIRO (Australia) Postdoctoral Fellowship
- 1983-1984 Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellowship
- 1999-2000 Willie Commelin Scholten Foundation Visiting Chair of Phytopathology, The Netherlands
- 2004-2004 Fulbright Foundation, Visiting Lecturer, Egypt
- 2004-2011 Guest Professor, Nanjing Agricultural University, China
- 2009-2011 Guest Professor, Northwest Agricultural and Forestry University, Yangling, China
Research Interests - Systems biology of infectious disease
- Comparative and functional genomics of oomycete plant pathogens
- Molecular analysis of oomycete virulence proteins, especially effectors
- Functional genomics of quantitative disease resistance and infection responses in plants
- Computational prediction of gene functions
- Mathematical modeling of complex cellular responses
Biography Brett Tyler is professor at the Virginia Bioinformatics Institute and at the Department of Plant Pathology, Physiology and Weed Science at Virginia Polytechnic Institute and State University. Prior to joining VBI in 2002, he was a faculty member in the Department of Plant Pathology at the University of California, Davis for 14 years. Dr Tyler has been a Damon Runyon-Walter Winchell Cancer Fund fellow, Willie Commelin Scholten Foundation Visiting Chair of Phytopathology in The Netherlands, a Fulbright Lecturer, a National Science Foundation Distinguished Lecturer, and a recipient of the American Phytopathological Society's Noel T. Keen Award for Research Excellence in Molecular Plant Pathology. He is Coordinator of the International Phytophthora Genome Initiative and Coordinator of the Oomycete Molecular Genetics Research Collaboration Network.
His research interests include the comparative and functional genomics of oomycete plant pathogens, the molecular analysis of oomycete virulence (effector) proteins, the functional genomics of quantitative disease resistance and infection responses in plants, computational prediction of gene functions, and mathematical modeling of complex cellular responses. A team led by him recently published the identification of phosphatidylinositol-3-phosphate as the cell entry receptor for oomycete and fungal effector proteins, in the journal Cell.
Selected Publications
Tyler BM. Viewing the microbial world through the lens of the Gene Ontology. Trends Microbiol. 2009;17:259–261.
Zhou L, Mideros SX, Bao L, et al. Infection and genotype remodel the entire soybean transcriptome. BMC Genomics. 2009;10:49.
Tyler BM. Entering and breaking: virulence effector proteins of oomycete plant pathogens. Cell Microbiol. 2009;11:13–20.
Dou D, Kale SD, Wang X, et al. RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery. Plant Cell. 2008;20:1930–1947.
Jiang RH, Tripathy S, Govers F, Tyler BM. RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members. Proc Natl Acad Sci U S A. 2008;105:4874–4879.
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