© 2000 - 2014 Virginia Bioinformatics Institute
Thursday, 24 April 2014
Mittelman, David , Ph.D.
Faculty - Mittelman, David

Associate Professor, Virginia Bioinformatics Institute
Associate Professor, Department of Biological Sciences, Virginia Tech

Phone: (540) 231-6430
Email: mittelma@vbi.vt.edu
Fax: 540-231-2606

Genetics and Genomic Medicine Lab | Publications | Mittelman Lab at VT


  • Administrative Assistant: Jodi Lewis
    Phone: (540) 231-0714
    Email: jlewis@vbi.vt.edu

Professional Preparation

  • Baylor College of Medicine, Biochemistry, Ph.D., 2007
  • UT Southwestern Medical Center, Center for Human Growth and Development, Research Associate, 1997-2002


  • 2009-2010  Baylor College of Medicine, NRSA Fellow
  • 2007-2009  Baylor College of Medicine, Human & Molecular Genetics

Research Interests

  • Stress-induced mutatagenesis in mammalian systems
  • Genetic and epigenetic pathways to genome instability
  • Zinc-finger nuclease-mediated manipulation of the genome
  • Next-generation sequencing-based analysis of genome instability


David Mittelman completed his graduate studies at Baylor College of Medicine, where he received his Ph.D. in 2007. Prior to graduate school, he was a member of the research staff in the McDermott Center for Human Growth and Development, at UT Southwestern Medical Center. After his graduate studies, Dr. Mittelman completed his postdoctoral training in the Department of Human and Molecular Genetics at Baylor College of Medicine. In 2009, Dr. Mittelman was awarded the Ruth L. Kirschstein National Research Service Award, and began an independent research program at the Human Genome Sequencing Center at Baylor. Currently, Dr. Mittelman is an associate professor at the Virginia Bioinformatics Institute and an associate professor in the Department of Biological Sciences at Virginia Tech.

Selected Publications

Mackay TFC RS Stone EA Barbadilla A Ayroles JF Zhu D Casillas S Han Y Magwire MM Cridland JM et al. The Drosophila Genetic Reference Panel: A Community Resource for Analysis of Population Genomics and Quantitative Traits. Nature. 2012;482(7384):173–8.

Mittelman D, Wilson JH. Stress, genomes, and evolution. Cell Stress Chaperones. 2010;15:463–466.

Mittelman D, Sykoudis K, Hersh M, Lin Y, Wilson JH. Hsp90 modulates CAG repeat instability in human cells. Cell Stress Chaperones. 2010;15:753–759.

Mittelman D, Moye C, Morton J, et al. Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells. Proc Natl Acad Sci U S A. 2009;106:9607–9612.