© 2000 - 2012 Virginia Bioinformatics Institute
Wednesday, 16 May 2012
Settlage, Robert , PhD
Faculty - Settlage, Robert

Director, Data Analysis Core

Phone: (540) 231-2777
Email: rsettlage@vbi.vt.edu
Fax:

Cyberinfrastructure Division | Data Analysis Core | Laboratory Core | Publications


Professional Preparation

  • University of Virginia, Chemistry, PhD, 1999
  • California State University, Sacramento, Chemistry, BS, 1994
  • Six Signma Green Belt (Villanova)

Research Interests




Biography

Dr. Settlage is currently the Director of the VBI Data Analysis Core (DAC) at Virginia Tech.  He has also served as the VBI Proteomics Lab Lead.  He has an active interest in improving the human-computer interaction as it pertains to data analysis.  Prior to VBI, Dr. Settlage was both the Proteomic Automation Lab Lead and the Proteomics Informatics Lead at Merck & Co, Inc.  In these positions, Dr. Settlage led efforts to develop software for the massive throughput capabilities being developed in the automation lab.  An example of the production improvements that were realized through improved algorithms and computer interface, Merck proteomics experiments involving SILAC data analysis moved from a highly manual 2-FTE-month process to less than a 1-FTE-week process.  As the  Director of the DAC, Dr. Settlage is actively pursuing algorithms and interfaces to assist in NextGen sequencing efforts of the VBI Core Laboratory Facility.  Beyond process improvements allowing bench scientists to analyze and explore their data, Dr. Settlage hopes to further develop software interfaces that are suitable for the patient side of the personal genomics revolution.

Selected Publications


Paweletz CP, Wiener MC, Bondarenko AY, et al. Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry. J Proteome Res. 2010;9:1392–1401.

Lee AY, Paweletz CP, Pollock RM, et al. Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry. J Proteome Res. 2008.

Zhao X, Deyanova EG, Lubbers LS, et al. Differential mass spectrometry of rat plasma reveals proteins that are responsive to 17beta-estradiol and a selective estrogen receptor modulator PPT. J Proteome Res. 2008;7:4373–4383.

Angenstein F, Evans AM, Ling SC, et al. Proteomic characterization of messenger ribonucleoprotein complexes bound to nontranslated or translated poly(A) mRNAs in the rat cerebral cortex. J Biol Chem. 2005;280:6496–6503.

Angenstein F, Evans AM, Settlage RE, et al. A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci. 2002;22:8827–8837.