Virginia Bioinformatics Institute

Wednesday, 16 May 2012

Home » Faculty » Publications

Bassaganya-Riera, Josep , Ph.D.

Faculty - Publications - Bassaganya-Riera, Josep

Professor, Virginia Bioinformatics Institute
Professor, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences
Director, Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute
Adjunct Professor, Department of Biomedical Sciences and Pathobiology

Phone: (540) 231-7421
Email:jbassaga@vbi.vt.edu
Fax: 540-231-2606

Administrative Specialist: Patricia Boyle
Phone: (540) 231-7254
Email: paboyle@vbi.vt.edu
Fax:540-231-2606

Personal_Page | Nutritional Immunology and Molecular Medicine Laboratory | Nutritional Immunology and Molecular Medicine Laboratory Web Portal | Center for Modeling Immunity to Enteric Pathogens

Publications:

2012

Bassaganya-Riera J, Hontecillas R, Horne WT, et al. Conjugated linoleic modulates immune responses in patients with Mild to Moderately active Crohn's disease. Clinical Nutrition. 2012.

Bassaganya-Riera J, Viladomiu M, Pedragosa M, Simone C de, Hontecillas R. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLOS One. 2012.

Bassaganya-Riera J, Viladomiu M, Pedragosa M, et al. Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPARg to suppress colitis. PLOS One, In Press. 2012.

Lu P, Hontecillas R, Horne WT, et al. Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase component C-like 2. PLOS One. 2012.

Wendelsdorf KW J. Bassaganya-Riera K. Bisset S. Eubank R. Hontecillas and M. Marathe. ENteric Immunity SImulator: A tool for in silico study of gut immunopathologies. In: IEEE Trans. NanoBioScience. Atlanta, GA; 2012. IEEE International Conference on Bioinformatics and Biomedicine.

2011

Bassaganya-Riera J, Diguardo M, Climent M, et al. Activation of PPARgamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice. Br J Nutr. 2011;106(6):878–886. http://www.ncbi.nlm.nih.gov/pubmed/21736821

Bassaganya-Riera J, DiGuardo M, Viladomiu M, et al. Soluble Fibers and Resistant Starch Ameliorate Disease Activity in Interleukin-10. The Journal of Nutrition. 2011;141(7):1318–1325. http://jn.nutrition.org/content/141/7/1318.abstract

Bassaganya-Riera J, Guri AJ, Lu P, et al. Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor γ. Journal of Biological Chemistry. 2011;286(4):2504–2516. http://www.jbc.org/content/286/4/2504.abstract

Bisset K J. Bassaganya-Riera A. Carbo S. Eubank R. Hontecillas S. Hoops M. Marathe Y. Mei K.W. Wendelsdorf D. Xie and J-S. Yeom. High-performance interaction-based simulation of gut immunopathologies with ENISI.; 2011. Ieee Ipdps.

Guri AJ, Bassaganya-Riera J. Systemic Effects of White Adipose Tissue Dysregulation and Obesity-Related Inflammation. Obesity. 2011;19(4):689–700. http://dx.doi.org/10.1038%2Foby.2010.230

Guri AJ, Evans NP, Hontecillas R, Bassaganya-Riera J. T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. The Journal of Nutritional Biochemistry. 2011;22(9):812–819. http://www.sciencedirect.com/science/article/pii/S0955286310001701

Hontecillas R, Horne WT, Climent M, et al. Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease. Mucosal Immunol. 2011;4(3):304–313. http://dx.doi.org/10.1038%2Fmi.2010.75

Howard MD, Willis L, Wakarchuk W, et al. Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. Veterinary microbiology. 2011;153(1-2):163–172. http://www.sciencedirect.com/science/article/pii/S0378113511001362

Lewis SN, Brannan L, Guri AJ, et al. Dietary α-Eleostearic Acid Ameliorates Experimental Inflammatory Bowel Disease in Mice by Activating Peroxisome Proliferator-Activated Receptor-γ. PLoS One. 2011;6(8):e24031. http://dx.doi.org/10.1371%2Fjournal.pone.0024031

Lu P, Bevan D, Lewis S, Hontecillas R, Bassaganya-Riera J. Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics. Journal of Molecular Modeling. 2011;17(3):543–553. http://dx.doi.org/10.1007%2Fs00894-010-0748-y

Vroegrijk IOCM, van Diepen JA, van den Berg S, et al. Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. Food and chemical toxicology. 2011;49(6):1426–1430. http://www.sciencedirect.com/science/article/pii/S0278691511001177

Wendelsdorf KW, Bassaganya-Riera J, Bisset K, Eubank S, R. H, Marathe M. ENteric Immunity SImulator: A tool for in silico study of gut immunopathologies. Atlanta, GA; 2011. Proceedings of the IEEE International Conference on Bioinformatics and Biomedicine.

2010

Bassaganya-Riera J, Hontecillas R. Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2010;13:569–573. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20508519

Bassaganya-Riera J, Skoneczka J, Kingston DG, et al. Mechanisms of action and medicinal applications of abscisic Acid. Curr Med Chem. 2010;17:467–478. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20015036

Bassaganya-Riera J, Song R, Roberts PC, Hontecillas R. PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections. Viral Immunol. 2010;23:343–352. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20712478

Chafin C, Muse S, Hontecillas R, et al. Deletion of PPAR gamma in immune cells enhances susceptibility to antiglomerular basement membrane disease. Journal of inflammation research. 2010;3:127. http://www.dovepress.com/deletion-of-ppar-gamma-in-immune-cells-enhances-susceptibility-to-anti-peer-reviewed-article-JIR

Dyer MD, Neff C, Dufford M, et al. The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis. PLoS One. 2010;5:e12089. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20711500

Evans NP, Call JA, Bassaganya-Riera J, Robertson JL, Grange RW. Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice. Clin Nutr. 2010;29:391–398. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19897286

Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas R, Bassaganya-Riera J. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. J Nutr. 2010;140:515–521. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20089779

Fu Z, Zhang W, Zhen W, et al. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 2010;151:3026–3037. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20484465

Guill S, Hargens T, Nickols-Richardson S, et al. Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea. Metab Syndr Relat Disord. 2010;8:33–38. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19943797

Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clinical Nutrition. 2010;29(6):824–831. http://www.sciencedirect.com/science/article/pii/S0261561410000397

Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR γ axis. Clinical Nutrition. 2010;29(5):646–653. http://www.sciencedirect.com/science/article/B6WCM-4YJ140J-1/2/06ba39d85e868c00157bb562f89d34f6

Guri AJ, Misyak SA, Hontecillas R, et al. Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall. The Journal of Nutritional Biochemistry. 2010;21(12):1178–1185. http://www.sciencedirect.com/science/article/B6T8P-4Y7NDK4-4/2/e321470e157de1877d440745ea443f4e

Guri AJ, Mohapatra SK, Horne WT 2nd, Hontecillas R, Bassaganya-Riera J. The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol. 2010;10:60. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20537136

Jesmin, Rashid M, Jamil H, Hontecillas R, Bassaganya-Riera J. Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension. BMC Medical Genomics. 2010;3(1):45. http://www.biomedcentral.com/1755-8794/3/45

Lewis SN, Bassaganya-Riera J, Bevan DR. Virtual Screening as a Technique for PPAR Modulator Discovery. PPAR Res. 2010;2010:861238. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19746174

Mane SP, Dominguez-Bello MG, Blaser MJ, et al. Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses. J Bacteriol. 2010;192:3078–3092. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20400544

Mazzei J H. Zhou B. Brayfield R. Hontecillas J. Bassaganya-Riera and E.M. Schmelz. Dietary sphingomyelin suppresses inflammation-driven colorectal cancer. Journal of Nutritional Biochemistry. 2010;In Press.

Mohapatra SK, Cole LE, Evans C, et al. Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection. BMC Infect Dis. 2010;10:10. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20082697

Mohapatra SK, Guri AJ, Climent M, et al. Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease. PLoS One. 2010;5:e10215. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20422041

Wendelsdorf K, Bassaganya-Riera J, Hontecillas R, Eubank S. Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease. J Theor Biol. 2010;264:1225–1239. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20362587

2009

Bassaganya-Riera J Sanchez S. de Horna A. Duran E. Orpi M. Ferrer G. Casagran O. Hontecillas R. F4/80hiCCR2hi macrophage infiltration into the intra-abdominal fat worsens the severity of IBD in obese mice with DSS colitis. e-SPEN Journal. 2009;4:90–97.

Bassaganya-Riera J, Misyak S, Guri AJ, Hontecillas R. PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation. Cell Immunol. 2009;258:138–146. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19423085

Carter AB, Misyak SA, Hontecillas R, Bassaganya-Riera J. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARgamma. PPAR Res. 2009;2009:498352. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19390648

Evans NP, Misyak SA, Robertson JL, Bassaganya-Riera J, Grange RW. Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention. Pm R. 2009;1:755–768. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19695529

Evans NP, Misyak SA, Robertson JL, Bassaganya-Riera J, Grange RW. Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy. Am J Phys Med Rehabil. 2009;88:502–522. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19454857

Hontecillas R, O'Shea M, Einerhand A, Diguardo M, Bassaganya-Riera J. Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. J Am Coll Nutr. 2009;28:184–195. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19828904

Meerts IA, Verspeek-Rip CM, Buskens CA, et al. Toxicological evaluation of pomegranate seed oil. Food Chem Toxicol. 2009;47:1085–1092. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19425183

Sassano G Sanderson P. Franx J. Groot J. van Straalen J. Bassaganya-Riera J. Analysis of pomegranate seed oil for the presence of jacaric acid. Journal of the Science of Food and Agriculture. 2009;6:1046–1052.

2008

Guri AJ, Hontecillas R, Bassaganya-Riera J. Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome. J Nutrigenet Nutrigenomics. 2008;1:126–135. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19776622

Guri AJ, Hontecillas R, Ferrer G, et al. Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem. 2008;19:216–228. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17618105

Hontecillas R, Diguardo M, Duran E, Orpi M, Bassaganya-Riera J. Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue. Clin Nutr. 2008;27:764–772. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18778878

Thakare K Shi W. Barbeau W.E. Bassaganya-Riera J. Hontecillas R. Investigation of colorform-methanol soluble wheat proteins and sphingolipids as potential dietary triggers of diabetes in BBdp rats. Food and Agricultural Immunology. 2008;19:25–48.

2007

Barbeau WE, Bassaganya-Riera J, Hontecillas R. Putting the pieces of the puzzle together – a series of hypotheses on the etiology and pathogenesis of type 1 diabetes. Med Hypotheses. 2007;68:607–619. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17045415

Bassaganya-Riera J, Guri AJ, Noble AM, et al. Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets. Am J Clin Nutr. 2007;85:824–836. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17344506

Guri AJ, Hontecillas R, Si H, Liu D, Bassaganya-Riera J. Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clin Nutr. 2007;26:107–116. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17000034

Hontecillas R, Bassaganya-Riera J. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis. J Immunol. 2007;178:2940–2949. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17312139

2006

Bassaganya-Riera J, Hontecillas R. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin Nutr. 2006;25:454–465. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16698153

Guri AJ, Hontecillas R, Bassaganya-Riera J. Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition. Clin Nutr. 2006;25:871–885. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17052808

2005

Bassaganya-Riera J Guri A. King J. Hontecillas R. Peroxisome Proliferator-Activated Receptors: the Nutritionally Controlled Molecular Networks that Integrate Inflammation, Immunity and metabolism. Current Nutrition & Food Science. 2005;1:179–187.

Hontecillas R, Bassaganya-Riera J, Wilson J, Hutto DL, Wannemuehler MJ. CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs. Immunology. 2005;115:127–135. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15819705

2004

Bassaganya-Riera J King J. Hontecillas R. Health Benefits of CLA: Lessons from Pig Models in Biomedical Research. Eur. Journal of Lipid Science and Technology. 2004;106:856–861. http://onlinelibrary.wiley.com/doi/10.1002/ejlt.200401067/pdf

Bassaganya-Riera J, Reynolds K, Martino-Catt S, et al. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology. 2004;127:777–791. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15362034

Bassaganya-Riera J, Thacker BJ, Yu S, Strait E, Wannemuehler MJ, Thacker EL. Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells. Viral Immunol. 2004;17:25–37. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15018660

O'Shea M, Bassaganya-Riera J, Mohede IC. Immunomodulatory properties of conjugated linoleic acid. Am J Clin Nutr. 2004;79:1199s–1206s. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15159257

2003

Bassaganya-Riera J, Pogranichniy RM, Jobgen SC, et al. Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression. J Nutr. 2003;133:3204–3214. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14519812

Hontecillas R, Bassaganya-Riera J. Differential requirements for proliferation of CD4+ and gammadelta+ T cells to spirochetal antigens. Cell Immunol. 2003;224:38–46. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14572799

2002

Bassaganya-Riera J Hontecillas R. Wannemuehler M.J. Nutritional impact of conjugated linoleic acid: a model funtional foo ingredient. In Vitro Cellular and Developmental Biology – Plant. 2002;38:241–246.

Bassaganya-Riera J, Hontecillas R, Beitz DC. Colonic anti-inflammatory mechanisms of conjugated linoleic acid. Clin Nutr. 2002;21:451–459. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12468364

Bassaganya-Riera J, Hontecillas R, Zimmerman DR, Wannemuehler MJ. Long-term influence of lipid nutrition on the induction of CD8(+) responses to viral or bacterial antigens. Vaccine. 2002;20:1435–1444. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11818164

Hontecillas R, Wannemeulher MJ, Zimmerman DR, et al. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr. 2002;132:2019–2027. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12097686

2001

Bassaganya-Riera J, Hontecillas R, Zimmerman DR, Wannemuehler MJ. Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8(+) lymphocytes. J Nutr. 2001;131:2370–2377. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11533281

Bassaganya-Riera J, Hontecillas-Magarzo R, Bregendahl K, Wannemuehler MJ, Zimmerman DR. Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition, and immune competence. J Anim Sci. 2001;79:714–721. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11263832

2000

Waters WR, Hontecillas R, Sacco RE, et al. Antigen-specific proliferation of porcine CD8alphaalpha cells to an extracellular bacterial pathogen. Immunology. 2000;101:333–341. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11106936