© 2000 - 2014 Virginia Bioinformatics Institute
Wednesday, 16 April 2014
Mukhopadhyay, Biswarup , Ph.D.
Faculty - Mukhopadhyay, Biswarup

Adjunct Associate Professor
Associate Professor, Department of Biochemistry, Virginia Tech
Adjunct Associate Professor, Department of Biological Sciences, Virginia Tech
Adjunct Associate Professor, Department of Internal Medicine, Virginia Tech Carilion School of Medicine

Phone: (540) 231-8015
Email: biswarup@vt.edu
Fax: 540-231-2606

Publications | NSF-REU Site: Microbiology in the Post Genome Era


  • Administrative Assistant: Jodi Lewis
    Phone: (540) 231-0714
    Email: jlewis@vbi.vt.edu

Professional Preparation

  • University of Iowa (Laboratory of Professor Lacy Daniels), Microbiology, Ph.D., 1993
  • University of Illinois at Urbana-Champaign (Laboratory of Professor Ralph S. Wolfe), postdoctoral training, 1993-2001

Research Interests

  • Methanogenic archaea
  • Remnants or precursors of sulfate reduction pathway genes
  • Redox regulation of energy metabolism
  • Structure-function relationships in archaeal-type phosphoenolpyruvate carboxylase
  • Coal bed microbiology - bioconversion of coal to methane, and mitigation of methane-induced mine explosion
  • Mycobacterial metabolism and tuberculosis [a collaboration with Dr. Endang Purwantini (the lead), Johns Hopkins University, Rotinsulu Pulmonary Hospital (Bandung, Indonesia), and Institut Teknolgi (Bandung, Indonesia) ]
  • Role of coenzyme F420 in sensing, detoxification, cell material biosynthesis and biodegradation (learning from the archaea for mycobacterial research) [a collaboration with Dr. Endang Purwantini]


Biswarup Mukhopadhyay is an associate professor at the Virginia Bioinformatics Institute and adjunct associate professor in Virginia Tech's Departments of Biochemistry and Biological Sciences. Mukhopadhyay joined VBI following his postdoctoral training in the laboratory of Prof. Ralph S. Wolfe at the University of Illinois. Prior to his graduate training in the Prof. Lacy Daniels' laboratory at the University of Iowa, he worked as a biochemical engineer for Hindustan Antibiotics Limited in India. Mukhopadhyay's group studies the biochemical mechanisms used by microorganisms to survive under extreme conditions with specific focus on the methanogenic archaea, natural gas production and tuberculosis. They also examine the structure-function relationships of two CO2-fixing enzymes (PEPCK and PEPC) with relevance in type 2 diabetes and production of chemicals and food crop.

Selected Publications

Susanti D, Mukhopadhyay B. An intertwined evolutionary history of methanogenic archaea and sulfate reduction. PLoS One. 2012;7:e45313.

Susanti D, Johnson EF, Rodriguez JR, et al. Complete Genome Sequence of Desulfurococcus fermentans, a Hyperthermophilic Cellulolytic Crenarchaeon Isolated from a Freshwater Hot Spring in Kamchatka, Russia. J Bacteriol. 2012;194:5703–5704.

Dharmarajan L, Kraszewski JL, Mukhopadhyay B, Dunten PW. Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate. Proteins. 2011;79:1820–1829.

Purwantini E, Mukhopadhyay B. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106(15):6333–6338.

Dharmarajan L, Kraszewski JL, Mukhopadhyay B, Dunten PW. Expression, purification and crystallization of an archaeal-type phosphoenolpyruvate carboxylase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:1193–1196.